Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

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click and please click
^use head phones

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.  

Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

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I... answered. You didn't see the answer, Bearsy.

It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.

As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

Post edited at 6:58 pm on Aug. 28, 2008 by TheOtherHorseman

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"My name is Ozymandias, King of Kings:
Look on my works, ye Mighty, and despair!"

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Quote: from Its Bearsy Bitch at 9:55 pm on Aug. 28, 2008

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.

Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

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I... answered. You didn't see the answer, Bearsy.

It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.

As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

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"acts on" what does that mean?

Wait a minute- how does it get out of the brain or spine and back to the bloodstream

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click and please click
^use head phones

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Quote: from TheOtherHorseman at 6:58 pm on Aug. 28, 2008

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Quote: from Its Bearsy Bitch at 9:55 pm on Aug. 28, 2008

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.    

 Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

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 I... answered. You didn't see the answer, Bearsy.  

 It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.  

 As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

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"acts on" what does that mean?

Wait a minute- how does it get out of the brain or spine and back to the bloodstream

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Acts on, like has an effect on.

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and victorious in war shall be made glorious in peace.

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Quote: from Its Bearsy Bitch at 3:02 am on Aug. 29, 2008

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Quote: from TheOtherHorseman at 6:58 pm on Aug. 28, 2008

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Quote: from Its Bearsy Bitch at 9:55 pm on Aug. 28, 2008

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.

  Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

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  I... answered. You didn't see the answer, Bearsy.

  It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.

  As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

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 "acts on" what does that mean?  

 Wait a minute- how does it get out of the brain or spine and back to the bloodstream

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How is it that you cannot understand this? If you can't understand the phrasing all this is too high level for you to understand anyway.

Acts on, like has an effect on.

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I know what the phrase acts on means but I want to know  what it really means in this particular situation.

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click and please click
^use head phones

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Quote: from TheOtherHorseman at 6:58 pm on Aug. 28, 2008

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Quote: from Its Bearsy Bitch at 9:55 pm on Aug. 28, 2008

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.    

 Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

---

 

 I... answered. You didn't see the answer, Bearsy.  

 It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.  

 As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

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"acts on" what does that mean?

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Blocks.

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Wait a minute- how does it get out of the brain or spine and back to the bloodstream

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The same way anything gets out of anywhere. Venous drainage.

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"My name is Ozymandias, King of Kings:
Look on my works, ye Mighty, and despair!"

he's telling me what the cocaine causes neurotransmitters do but he's not telling me how it causes them to do that

I don't know how to phrase this

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click and please click
^use head phones

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like physically  

he's telling me what the cocaine causes neurotransmitters do but he's not telling me how it causes them to do that  

I don't know how to phrase this

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like physically  

he's telling me what the cocaine causes neurotransmitters do but he's not telling me how it causes them to do that  

I don't know how to phrase this

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Physically, it BLOCKS the molecular machinery that brings it back into the cell. A more specific answer is not needed, and nor can it be given without producing a 3-dimensional image (perhaps timelapse) of precisely how the two tertiary structures interact.

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"My name is Ozymandias, King of Kings:
Look on my works, ye Mighty, and despair!"

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Quote: from Its Bearsy Bitch at 10:02 pm on Aug. 28, 2008

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Quote: from TheOtherHorseman at 6:58 pm on Aug. 28, 2008

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Quote: from Its Bearsy Bitch at 9:55 pm on Aug. 28, 2008

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^You don't see the question Horseman, what I'm wanting to know is HOW it prevents dopamine from being reabsorved from the synaptic cleft.

  Oh and here's a new question, where does the cocaine go when it... wheres out or whatever. or why does it where out

---

  I... answered. You didn't see the answer, Bearsy.

  It acts on the neuronal membrane-spanning dopamine transporter protein which mediates transport.

  As for what happens to the cocaine, it continues merrily on in circulation until it is broken down, undoubtedly in the liver, and what is left of it is filtered out of circulation in the kidney, and then you piss it out.

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 "acts on" what does that mean?

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Blocks.

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Wait a minute- how does it get out of the brain or spine and back to the bloodstream

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The same way anything gets out of anywhere. Venous drainage.

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yeah I know stuff gets blocked, but how is the cocaine doing this?! Are there little pieces of powdered cocaine sitting in the doorway of the dopamine receptors? Like literally the powder is sitting there and dopamine is bumping into a big wall of cocaine it can't get through?

To the second question TY very much for answering

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click and please click
^use head phones

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Quote: from Its Bearsy Bitch at 10:09 pm on Aug. 28, 2008

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like physically

 he's telling me what the cocaine causes neurotransmitters do but he's not telling me how it causes them to do that

 I don't know how to phrase this

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Physically, it BLOCKS the molecular machinery that brings it back into the cell. A more specific answer is not needed, and nor can it be given without producing a 3-dimensional image (perhaps timelapse) of precisely how the two tertiary structures interact.

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Due to its structure, it is able to interact in such a way with the dopamine transport molecule so as to render it inoperable. How, specifically? Either a molecule fits into the spot normally occupied by dopamine to be transported and prevents dopamine from binding (this is known as competitive inhibition) or it induces some sort of conformational change which renders it extremely difficult or impossible for dopamine to bind (non-competitive inhibition).

Do I know or particularly care which of the two is happening here? Not especially. You can do your own research.

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"My name is Ozymandias, King of Kings:
Look on my works, ye Mighty, and despair!"

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yeah I know stuff gets blocked, but how is the cocaine doing this?! Are there little pieces of powdered cocaine sitting in the doorway of the dopamine receptors? Like literally the powder is sitting there and dopamine is bumping into a big wall of cocaine it can't get through?

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Quote: from TheOtherHorseman at 7:10 pm on Aug. 28, 2008

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Quote: from Its Bearsy Bitch at 10:09 pm on Aug. 28, 2008

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like physically    

  he's telling me what the cocaine causes neurotransmitters do but he's not telling me how it causes them to do that    

  I don't know how to phrase this

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 Physically, it BLOCKS the molecular machinery that brings it back into the cell. A more specific answer is not needed, and nor can it be given without producing a 3-dimensional image (perhaps timelapse) of precisely how the two tertiary structures interact.

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I've seen videos of how antidepressants work but I get the sense they're making shit up as I can't imagine serotonin bumping into a wall of paxil and getting all butthurt because it can't get in the receptor cos the pieces of paxil are so fat

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