6:07 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
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greatescape
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6:11 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
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Quote: from greatescape11 at 6:08 pm on Aug. 28, 2008
6:12 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
marshmellowman
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Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters
amirite
No, not really. It depends from drug to drug, but usually either the drug inhibits the breakdown of neurotransmitter causing large amounts to remain inside the synaptic cleft (such as with MDMA I believe), or the drug can prevent the neurotransmitter from forming causing less action potentials to be transferred and hence less propagation of the impulse. Or it can be something else too. There're lots of ways drugs can have effects on the brain.
I know but I'm saying for example, I was just asking how it gets up there in the first place and tricks the brain into doing stuff
But you said all this shit about 'fizzing'? Where'd that come from?
It goes through the blood vessels that feed the brain or the mucousal membrane and even then it has to cross the blood brain barrier that prevents like the absorption depending on it's structure and composition.
It doesn't trick anything. The synapses at which these occur (like their location) and which part of the brain that controls is what gives the specific effect on the brain and how they're not all the same.
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6:12 pm on Aug. 28, 2008 | Joined: Feb. 2007 | Days Active: 763 Join to learn more about marshmellowmanEngland, United Kingdom | StraightMale | Posts: 24,469 | Points: 43,376
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Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain.
mmk so here I am I'm cocaine and I'm in your cns and my chemicals are meeting yours
so now... little pieces of my chemicals are going to go directly into your stuff and block shit with my physical force
No. Don't say CNS when you mean spinal cord, they're not the same thing. CNS encompasses both the spinal cord and the brain.
That when cocaine 'arrives' to the brain inhibiting the uptake of many neurotransmitters in specific ratios (such as dopamine, serotonin, noradrenalin). It's all really complicated, so just think that these then have a knock-on effect and produces the effects of cocaine.
------- and victorious in war shall be made glorious in peace.
6:17 pm on Aug. 28, 2008 | Joined: Feb. 2007 | Days Active: 763 Join to learn more about marshmellowmanEngland, United Kingdom | StraightMale | Posts: 24,469 | Points: 43,376
Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain.
so do the drugs actually go in your brain
and if I'm cocaine and I'm in your brain what will I do now
6:17 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
mmk so here I am I'm cocaine and I'm in your cns and my chemicals are meeting yours
so now... little pieces of my chemicals are going to go directly into your stuff and block shit with my physical force
No. Don't say CNS when you mean spinal cord, they're not the same thing. CNS encompasses both the spinal cord and the brain.
That when cocaine 'arrives' to the brain inhibiting the uptake of many neurotransmitters in specific ratios (such as dopamine, serotonin, noradrenalin). It's all really complicated, so just think that these then have a knock-on effect and produces the effects of cocaine.
I know what it is now I looked it up on Wiki mmmk
But I want to know how, physically, it is inhibiting the neurotransmitters
6:19 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
marshmellowman
wewerepromisedjetpacks Patron Support Leader Tech Support Leader
But I want to know how, physically, it is inhibiting the neurotransmitters
Like does it block them
It can prevent the neurotransmitter from being uptaken for example by binding to the receptors on the post-synaptic membrane, which means they won't be broken down and instead remain in the synaptic cleft.
Post edited at 6:24 pm on Aug. 28, 2008 by marshmellowman
------- and victorious in war shall be made glorious in peace.
6:22 pm on Aug. 28, 2008 | Joined: Feb. 2007 | Days Active: 763 Join to learn more about marshmellowmanEngland, United Kingdom | StraightMale | Posts: 24,469 | Points: 43,376
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I'm sure they do more than inhibit I've read that amphetamine causes rapid fire
6:24 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain.
so do the drugs actually go in your brain
and if I'm cocaine and I'm in your brain what will I do now
Stimulants do not affect the brain itself. It effects the signals being past from one part of the brain to the other. It speeds the signals up. So imaging you brain as it is normally.... and you have electric signals pasing from one part to another.... well if you take a stimulant.... these signals jump around faster... causing you to act without thinking. It speeds up the signals by increasing 2 main chemicals that are located behind the blood brain barrier in the "Central Nervious System" These 2 main chemicals are called "dopamine" & "adrenaline"
I'm sure they do more than inhibit I've read that amphetamine causes rapid fire
it is indeed a trick
Like I said they don't all work exactly the same, but this is a rough but accurate outline. I honestly don't know what answer you're expecting.
------- and victorious in war shall be made glorious in peace.
6:26 pm on Aug. 28, 2008 | Joined: Feb. 2007 | Days Active: 763 Join to learn more about marshmellowmanEngland, United Kingdom | StraightMale | Posts: 24,469 | Points: 43,376
Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain.
so do the drugs actually go in your brain
and if I'm cocaine and I'm in your brain what will I do now
Stimulants do not affect the brain itself. It effects the signals being past from one part of the brain to the other. It speeds the signals up. So imaging you brain as it is normally.... and you have electric signals pasing from one part to another.... well if you take a stimulant.... these signals jump around faster... causing you to act without thinking. It speeds up the signals by increasing 2 main chemicals that are located behind the blood brain barrier in the "Central Nervious System" These 2 main chemicals are called "dopamine" & "adrenaline"
yeah I no what it does but... does anyone know how it physically does it? o_0
It's very possible that this is a mystery
I mean maybe when the cocaine meets the CNS it tickles something in it that would normally only be tickled when dopamine is really supposed to be upped, and the tickling reacts by making it send the desired electric signal
because otherwise how would it know which signals to send
6:31 pm on Aug. 28, 2008 | Joined: July 2008 | Days Active: 437 Join to learn more about BearsyCalifornia, United States | Posts: 24,731 | Points: 21,585
TheOtherHorseman
Where shall wisdom be found? Patron Support Leader
Cocaine is a multiple agonist that acts as a reuptake inhibitor. It produces its physiological changes by prolonging dopamine's, say, action by preventing it from being reabsorbed from the synaptic cleft back into the neuron. The how of it is by interfering with the transport proteins which actually enable the large neurotransmitter molecules to pass through the lipid bilayer which would normally be sealed to such large things.
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