Adding Reply Archived Topic: It will not be bumped to the top of the forum. Topic When people snort drugs, how do they get to the brain? Membername   Not a member? Sign Up Free (takes 20 seconds) Password   Forgotten your password? Post Font: Verdana Arial Black Georgia Comic Sans Impact   Size: Tiny Normal Big Huge   Color: Default Dark Red Red Orange Brown Green Olive Cyan Blue Dark Blue Indigo Black [ Check Spelling ] [ Post Preview ] [ LiveTags ] FAQ Keyword Search: Post Options Favorites Manager Notify me of new replies to this topic by email Notify me of new replies to this topic by private message Original Post Bearsy Posted at 5:51 pm on Aug. 28, 2008 my guess: First they go to the lungs then they get absorbed in the lungs in go in the bloodstream with the oxygen and then they go up to the brain... but then once up to the brain how do they work does the brain have to soak them up or something

Replies TheOtherHorseman Posted at 8:07 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 11:06 pm on Aug. 28, 2008 I don't know if that makes sense but I'll accept it for now It does. Bearsy Posted at 8:06 pm on Aug. 28, 2008 I don't know if that makes sense but I'll accept it for now TheOtherHorseman Posted at 7:59 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:56 pm on Aug. 28, 2008 and yet if one took more they'd get high for longer. Is the luge ride blocked too  if there's more   Learning is fun If there's more of it, on average it will take longer for enough of it to float into the capillaries and go away to make you stop being high.. Bearsy Posted at 7:56 pm on Aug. 28, 2008 and yet if one took more they'd get high for longer. Is the luge ride blocked too  if there's more Learning is fun TheOtherHorseman Posted at 7:50 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:48 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:42 pm on Aug. 28, 2008 Wait a minute how many doors are there?       Because if it only takes one molecule to block a door I don't see why more cocaine at ones does more to a person.    Okay, so it makes sense that the cocaine doesn't block the door forever, right? Otherwise, you'd do cocaine once, and you'd be high for all of time.    Eventually, of its own accord, it leaves the door. The more cocaine you have floating around, the more likely a new molecule will randomly come in and bind again before dopamine can get in. but when the blood comes in to take the blood away doesn't everybody get washed out? so it's about likelihood. So if I put two molecules of cocaine in your brain you might get high but it's unlikely since they're the only guys floating about Once you get into tiny molecular levels, it becomes very much a game of probability. Andd, the blood doesn't come in and wash things out. Things diffuse into capillaries in their own sweet time and take the magical luge ride to veins. Bearsy Posted at 7:49 pm on Aug. 28, 2008 Quote: from marshmellowman at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 3:42 am on Aug. 29, 2008 Wait a minute how many doors are there?   Because if it only takes one molecule to block a door I don't see why more cocaine at ones does more to a person. There are a lot of doors (millions), so that more cocaine will block more doors, but there will be a plateau eventually where if you take more than x amount you'll still have the same effect because there are no more doors to block. EDIT: If you mean why the person isn't constantly feeling it's effects, then it's because the cocaine eventually leaves. It doesn't stay there forever. millions you say   Bearsy Posted at 7:49 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:44 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:40 pm on Aug. 28, 2008 That little bit on the bottom is the part which is the key, and the part it fits into is the keyhole. It doesn't matter what the rest of the key looks like, just the important part with all the ridges and such. the hexagon?? I was referring to the picture marshmellowman had, where you said they were different shapes. o i c Bearsy Posted at 7:48 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:42 pm on Aug. 28, 2008 Wait a minute how many doors are there?  Because if it only takes one molecule to block a door I don't see why more cocaine at ones does more to a person. Okay, so it makes sense that the cocaine doesn't block the door forever, right? Otherwise, you'd do cocaine once, and you'd be high for all of time. Eventually, of its own accord, it leaves the door. The more cocaine you have floating around, the more likely a new molecule will randomly come in and bind again before dopamine can get in. but when the blood comes in to take the blood away doesn't everybody get washed out? so it's about likelihood. So if I put two molecules of cocaine in your brain you might get high but it's unlikely since they're the only guys floating about marshmellowman Posted at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 3:42 am on Aug. 29, 2008 Wait a minute how many doors are there? Because if it only takes one molecule to block a door I don't see why more cocaine at ones does more to a person. There are a lot of doors (millions), so that more cocaine will block more doors, but there will be a plateau eventually where if you take more than x amount you'll still have the same effect because there are no more doors to block. EDIT: If you mean why the person isn't constantly feeling it's effects, then it's because the cocaine eventually leaves. It doesn't stay there forever. TheOtherHorseman Posted at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:44 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:40 pm on Aug. 28, 2008 That little bit on the bottom is the part which is the key, and the part it fits into is the keyhole.    It doesn't matter what the rest of the key looks like, just the important part with all the ridges and such. the hexagon?? I was referring to the picture marshmellowman had, where you said they were different shapes. TheOtherHorseman Posted at 7:44 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:42 pm on Aug. 28, 2008 Wait a minute how many doors are there?   Because if it only takes one molecule to block a door I don't see why more cocaine at ones does more to a person. Okay, so it makes sense that the cocaine doesn't block the door forever, right? Otherwise, you'd do cocaine once, and you'd be high for all of time. Eventually, of its own accord, it leaves the door. The more cocaine you have floating around, the more likely a new molecule will randomly come in and bind again before dopamine can get in. Bearsy Posted at 7:44 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:40 pm on Aug. 28, 2008 That little bit on the bottom is the part which is the key, and the part it fits into is the keyhole. It doesn't matter what the rest of the key looks like, just the important part with all the ridges and such. the hexagon?? Bearsy Posted at 7:42 pm on Aug. 28, 2008 Wait a minute how many doors are there?   Because if it only takes one molecule to block a door I don't see why more cocaine at once does more to a person. marshmellowman Posted at 7:42 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 3:39 am on Aug. 29, 2008 Quote: from marshmellowman at 7:36 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 3:31 am on Aug. 29, 2008 What if your parking space is blocked by empty boxes, no problem       I think it would have to be a certain size.       I'm getting confused though. could two molecules be the same shape ever?     Well it'd just have to be similar enough to fit into the active site and form bonds with the active site (so not 'fall out'), but can have like one or two different functional groups which means it stays there but does nothing. Picture from wikipedia below:     but not the same shape Not the exact same shape, no, otherwise it'd be an agonist and not an antagonist (assuming the same bonds form between the substrate and the active site). But it can't be totally different otherwise it won't fit in at all and it won't block it. Bearsy Posted at 7:41 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:36 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:32 pm on Aug. 28, 2008 Quote: from TheOtherHorseman at 7:28 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 10:26 pm on Aug. 28, 2008 sooo the molecules of cocaine are shaped so funny no one can get in Okay, imagine a doorknob with a keyhole. One key unlocks the door (Key 1), but many keys might be able to be inserted. Put a key that doesn't unlock it into the door. Without removing that key, can you now unlock the door with Key 1? That is what is happening. It is a similar enough shape so as to get in, but different enough so that nothing happens, and the real key finds that its seat on the bus is taken. Oh right, right. Yeah it makes fine sense... so it is only one cocaine molecule in the door or it is multiple It only takes one. If it helps you to envision it, cocaine IS bigger. (the relative size is still irrelevant here, though) DOPAMINE COCAINE AGAIN ok. I see this. You snort the cocaine and it goes in your membrane and blood and all up in you brain and in there it's molecules start blocking the door and thirty seconds late you have tons of dopamine in action and you feel them Most recent 15 of 74 previous replies displayed.