Pages: 1 2 3  Next -- Posted by Bearsy at 5:51 pm on Aug. 28, 2008 my guess: First they go to the lungs then they get absorbed in the lungs in go in the bloodstream with the oxygen and then they go up to the brain... but then once up to the brain how do they work does the brain have to soak them up or something -- Posted by drifting at 5:53 pm on Aug. 28, 2008 Nope. Mucus Membrane. They get absorbed on the blood rich mucus membrane. -- Posted by PewPew at 5:53 pm on Aug. 28, 2008 Alters Brain Chemistry and ways you process things and such. -- Posted by robdude at 5:53 pm on Aug. 28, 2008 House would know -- Posted by Bearsy at 5:55 pm on Aug. 28, 2008 Quote: from drifting at 5:53 pm on Aug. 28, 2008 Nope. Mucus Membrane. They get absorbed on the blood rich mucus membrane. o i c. Ok then what -- Posted by marshmellowman at 5:55 pm on Aug. 28, 2008 Quote: from drifting at 1:53 am on Aug. 29, 2008 Nope. Mucus Membrane. They get absorbed on the blood rich mucus membrane. Assuming the drug can pass through the blood-brain barrier, otherwise it's useless what you snort. -- Posted by greatescape at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane. In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier -- Posted by Bearsy at 5:57 pm on Aug. 28, 2008 Ok tell me how this works, does the brain just soak your powder up like a sponge and go, "this texture makes me want to increase my dopamine!" I think not. I need to know, they don't even have this information on the Internet. -- Posted by drifting at 5:57 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 8:55 pm on Aug. 28, 2008 Quote: from drifting at 5:53 pm on Aug. 28, 2008 Nope.    Mucus Membrane. They get absorbed on the blood rich mucus membrane. o i c.   Ok then what I assume the chemicals then inhibit, or stimulate senders/receptors in the brain, causing the brain to misfire, throwing you into an alter state of consciousness. -- Posted by Bearsy at 5:58 pm on Aug. 28, 2008 Quote: from greatescape11 at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane. In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier so do they not really go in your brain -- Posted by Bearsy at 6:01 pm on Aug. 28, 2008 Quote: from drifting at 5:57 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 8:55 pm on Aug. 28, 2008 Quote: from drifting at 5:53 pm on Aug. 28, 2008 Nope.   Mucus Membrane. They get absorbed on the blood rich mucus membrane. o i c.  Ok then what I assume the chemicals then inhibit, or stimulate senders/receptors in the brain, causing the brain to misfire, throwing you into an alter state of consciousness. Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters amirite -- Posted by drifting at 6:02 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 9:01 pm on Aug. 28, 2008 Quote: from drifting at 5:57 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 8:55 pm on Aug. 28, 2008 Quote: from drifting at 5:53 pm on Aug. 28, 2008 Nope.        Mucus Membrane. They get absorbed on the blood rich mucus membrane. o i c.       Ok then what    I assume the chemicals then inhibit, or stimulate senders/receptors in the brain, causing the brain to misfire, throwing you into an alter state of consciousness. Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters amirite Thats how I understand it. -- Posted by marshmellowman at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:01 am on Aug. 29, 2008 Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters amirite No, not really. It depends from drug to drug, but usually either the drug inhibits the breakdown of neurotransmitter causing large amounts to remain inside the synaptic cleft (such as with MDMA I believe), or the drug can prevent the neurotransmitter from forming causing less action potentials to be transferred and hence less propagation of the impulse. Or it can be something else too. There're lots of ways drugs can have effects on the brain. -- Posted by greatescape at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 7:58 pm on Aug. 28, 2008 Quote: from greatescape11 at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane.    In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier so do they not really go in your brain Yes they do.....how was that hard to understand at all? -- Posted by Bearsy at 6:06 pm on Aug. 28, 2008 Quote: from marshmellowman at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:01 am on Aug. 29, 2008 Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters    amirite No, not really. It depends from drug to drug, but usually either the drug inhibits the breakdown of neurotransmitter causing large amounts to remain inside the synaptic cleft (such as with MDMA I believe), or the drug can prevent the neurotransmitter from forming causing less action potentials to be transferred and hence less propagation of the impulse. Or it can be something else too. There're lots of ways drugs can have effects on the brain. I know but I'm saying for example, I was just asking how it gets up there in the first place and tricks the brain into doing stuff -- Posted by Bearsy at 6:07 pm on Aug. 28, 2008 Quote: from greatescape11 at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 7:58 pm on Aug. 28, 2008 Quote: from greatescape11 at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane.   In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier so do they not really go in your brain Yes they do.....how was that hard to understand at all? I was thinking the  cns is just in the spine -- Posted by greatescape at 6:08 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 8:07 pm on Aug. 28, 2008 Quote: from greatescape11 at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 7:58 pm on Aug. 28, 2008 Quote: from greatescape11 at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane.       In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier so do they not really go in your brain    Yes they do.....how was that hard to understand at all? I was thinking the cns is just in the spine Oh dear god. -- Posted by Bearsy at 6:11 pm on Aug. 28, 2008 mmk so here I am I'm cocaine and I'm in your cns and my chemicals are meeting yours so now... little pieces of my chemicals are going to go directly into your stuff and block shit with my physical force -- Posted by Bearsy at 6:12 pm on Aug. 28, 2008 Quote: from greatescape11 at 6:08 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 8:07 pm on Aug. 28, 2008 Quote: from greatescape11 at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 7:58 pm on Aug. 28, 2008 Quote: from greatescape11 at 5:55 pm on Aug. 28, 2008 Absorbed through the mucos membrane, which then allows them to enter the mucus membrane.    In order to get to the brain they have to ahve the right chemical properties to cross the blood brain barrier so do they not really go in your brain   Yes they do.....how was that hard to understand at all? I was thinking the  cns is just in the spine Oh dear god. wtf? you're so condescending that's not a hard thing to confuse? -- Posted by marshmellowman at 6:12 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:06 am on Aug. 29, 2008 Quote: from marshmellowman at 6:04 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:01 am on Aug. 29, 2008 Oh right... so the chemicals in the powdered drugs would combine with the chemicals in the cns and they would fizz and the cns would think it's supposed to fire extra shots of feel good neurotransmitters   amirite No, not really.    It depends from drug to drug, but usually either the drug inhibits the breakdown of neurotransmitter causing large amounts to remain inside the synaptic cleft (such as with MDMA I believe), or the drug can prevent the neurotransmitter from forming causing less action potentials to be transferred and hence less propagation of the impulse. Or it can be something else too. There're lots of ways drugs can have effects on the brain. I know but I'm saying for example, I was just asking how it gets up there in the first place and tricks the brain into doing stuff But you said all this shit about 'fizzing'? Where'd that come from? It goes through the blood vessels that feed the brain or the mucousal membrane and even then it has to cross the blood brain barrier that prevents like the absorption depending on it's structure and composition. It doesn't trick anything. The synapses at which these occur (like their location) and which part of the brain that controls is what gives the specific effect on the brain and how they're not all the same. -- Posted by 69565697695656 at 6:15 pm on Aug. 28, 2008 Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain. -- Posted by marshmellowman at 6:17 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:11 am on Aug. 29, 2008 mmk so here I am I'm cocaine and I'm in your cns and my chemicals are meeting yours so now... little pieces of my chemicals are going to go directly into your stuff and block shit with my physical force No. Don't say CNS when you mean spinal cord, they're not the same thing. CNS encompasses both the spinal cord and the brain. That when cocaine 'arrives' to the brain inhibiting the uptake of many neurotransmitters in specific ratios (such as dopamine, serotonin, noradrenalin). It's all really complicated, so just think that these then have a knock-on effect and produces the effects of cocaine. -- Posted by Bearsy at 6:17 pm on Aug. 28, 2008 Quote: from 69565697695656 at 6:15 pm on Aug. 28, 2008 Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain. so do the drugs actually go in your brain and if I'm cocaine and I'm in your brain what will I do now -- Posted by Bearsy at 6:19 pm on Aug. 28, 2008 Quote: from marshmellowman at 6:17 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:11 am on Aug. 29, 2008 mmk so here I am I'm cocaine and I'm in your cns and my chemicals are meeting yours    so now... little pieces of my chemicals are going to go directly into your stuff and block shit with my physical force No. Don't say CNS when you mean spinal cord, they're not the same thing. CNS encompasses both the spinal cord and the brain. That when cocaine 'arrives' to the brain inhibiting the uptake of many neurotransmitters in specific ratios (such as dopamine, serotonin, noradrenalin). It's all really complicated, so just think that these then have a knock-on effect and produces the effects of cocaine. I know what it is now I looked it up on Wiki mmmk But I want to know how, physically, it is inhibiting the neurotransmitters Like does it block them -- Posted by marshmellowman at 6:22 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:19 am on Aug. 29, 2008 But I want to know how, physically, it is inhibiting the neurotransmitters   Like does it block them It can prevent the neurotransmitter from being uptaken for example by binding to the receptors on the post-synaptic membrane, which means they won't be broken down and instead remain in the synaptic cleft. -- Posted by Bearsy at 6:24 pm on Aug. 28, 2008 -_- I'm sure they do more than inhibit I've read that amphetamine causes rapid fire it is indeed a trick -- Posted by 69565697695656 at 6:25 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 6:17 pm on Aug. 28, 2008 Quote: from 69565697695656 at 6:15 pm on Aug. 28, 2008 Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain. so do the drugs actually go in your brain and if I'm cocaine and I'm in your brain what will I do now Stimulants do not affect the brain itself. It effects the signals being past from one part of the brain to the other. It speeds the signals up. So imaging you brain as it is normally.... and you have electric signals pasing from one part to another.... well if you take a stimulant.... these signals jump around faster... causing you to act without thinking. It speeds up the signals by increasing 2 main chemicals that are located behind the blood brain barrier in the "Central Nervious System" These 2 main chemicals are called "dopamine" & "adrenaline" -- Posted by marshmellowman at 6:26 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 2:24 am on Aug. 29, 2008 -_- I'm sure they do more than inhibit I've read that amphetamine causes rapid fire it is indeed a trick Like I said they don't all work exactly the same, but this is a rough but accurate outline. I honestly don't know what answer you're expecting. -- Posted by Bearsy at 6:31 pm on Aug. 28, 2008 Quote: from 69565697695656 at 6:25 pm on Aug. 28, 2008 Quote: from Its Bearsy Bitch at 6:17 pm on Aug. 28, 2008 Quote: from 69565697695656 at 6:15 pm on Aug. 28, 2008 Really strong stimulants will pass though something called the blood brain barrier. Even caffeine can do this if it is taken at a higher dose. Weither you snort stimulant powder, or swallow it... makes no difference... the powder will instantly desolve in the blood stream, which then sends signals back up your spinal cord, and though the blood brain barrior, located at the frontal area of the brain. so do the drugs actually go in your brain    and if I'm cocaine and I'm in your brain what will I do now Stimulants do not affect the brain itself. It effects the signals being past from one part of the brain to the other. It speeds the signals up. So imaging you brain as it is normally.... and you have electric signals pasing from one part to another.... well if you take a stimulant.... these signals jump around faster... causing you to act without thinking. It speeds up the signals by increasing 2 main chemicals that are located behind the blood brain barrier in the "Central Nervious System" These 2 main chemicals are called "dopamine" & "adrenaline" yeah I no what it does but... does anyone know how it physically does it? o_0 It's very possible that this is a mystery I mean maybe when the cocaine meets the CNS it tickles something in it that would normally only be tickled when dopamine is really supposed to be upped, and  the tickling reacts by making it send the desired electric signal because otherwise how would it know which signals to send -- Posted by TheOtherHorseman at 6:42 pm on Aug. 28, 2008 Cocaine is a multiple agonist that acts as a reuptake inhibitor. It produces its physiological changes by prolonging dopamine's, say, action by preventing it from being reabsorbed from the synaptic cleft back into the neuron. The how of it is by interfering with the transport proteins which actually enable the large neurotransmitter molecules to pass through the lipid bilayer which would normally be sealed to such large things. Pages: 1 2 3  Next